Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank

Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank

Background Many common neurological disorders are associated with advancing chronological age, but their association with biological age (BA) remains poorly understood. Methods We studied 325 870 participants in the UK Biobank without a diagnosed neurological condition at baseline and generated three previously-described measures of BA based on 18 routinely measured clinical biomarkers (PhenoAge, Klemera-Doubal method age (KDMAge), homeostatic dysregulation age).